Level demi Level harus mereka berdelapan lewati. Pandji (Pandji Pragiwaksono) terpaksa bertaruh akan kelangsungan hidup mereka, di dalam permainan Judi online yang tersebar ke para Raja Judi di seluruh dunia. Mereka yang telah dijebak oleh THE KING (Sophia Latjuba) bersama para pasukannya yang dipimpin oleh Isa (Donny Alamsyah) dan Bella (Hannah Al Rashid), serta seorang konspirator licik bernama Dr. Ke delapan agen rahasia (Arie Kriting, Babe Cabiita, Bintang Bete, Ernest Prakasa, Fico Fachriza, Ge Pamungkas, Kemal Palevi, Mongol) yang memakai nama samaran COMIC 8 kembali beraksi.

Making their memorable cameos in the action-packed, laugh-out-loud film are Nikita Mirzani, Agung Hercules, Agus Kuncoro, Candil, Gandhi Fernando, Cak Lontong, Joe P Project, Boy William, Ray Sahetapy and Bagus Netral. This sequel, Comic 8: 'Casino Kings Part 2' will blow your mind. A series of humorous events will tickle you as our heroes battle their way toward finding and apprehending The King, and each twist will keep you on the edge of your seat as you follow the adventure of these agents. Chintya, Indro and the Security Guard must fight for their survival against tough fighters in the Fighting Cage. At the same time, Indro Warkop, who is wanted by an Interpol Agent named Chintya (Prisia Nasution) is also trapped in the Online Gambling scheme on the hidden island with a Security Guard (Ence Bagus) who appears in the wrong time and place.

They also have to face the Master of Martial Arts, The Ghost (Yayan Ruhian), who resurfaced back into the world simply to eliminate Babe Cabiita. The eight of them must get through each life-threatening level together, facing a killer squad called The Hunters (Barry Prima, George Rudy, Lidya Kandou, Willy Dozan, Soleh Solihun, Sacha Stevenson) who keeps on hunting them to end their lives. Our secret agents must bet on their lives in the world's largest online gambling scheme whose players include renowned gamblers from around the globe. The eight secret agents (Arie Kriting, Babe Cabiita, Bintang Bete, Ernest Prakasa, Fico Fachriza, Ge Pamungkas, Kemal Palevi, Mongol) who adopted the code name COMIC 8 are back in action.They are led into a trap by THE KING (Sophia Latjuba) and her army, led by Isa (Donny Alamsyah) and Bella (Hannah Al Rashid), and a co-conspirator named Dr.

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